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The Institute for Therapeutic Discovery
Improving Health for Humans and Animals

THE FOLLOWING DOCUMENTS reflect the progression of a product from an idea to intellectual property in the form of a patent to laboratory and clinical work which results in a product to be licensed. This later work is then described in peer-reviewed, professional publications, and presentations of which several are listed below.

Representative Patents (of over 100 patents issued)
  • United States Patent: Treatment of Urinary Incontinence
  • United States Patent: Methods of Alleviating Symptoms Associated with Diabetes and Diabetic Neuropathy Comprising Administration of Low Levels of Antibodies.
  • United States Patent: Method for Treatment of Symptoms of Central Nervous System Disorders
  • United States Patent: Method for Treating Respiratory Distress by Sublingual Administration of DNA
  • United States Patent: Treatment of Cardiomyopathy
Peer-Reviewed Publications and Abstracts

"Microdose DNA for the Treatment of Acute and Chronic Respiratory Diseases and Otitis Media," Stephen Mamber, Ph.D., and John McMichael, PhD, The Journal of the American Nutraceutical Association, Vol. 9, No. 1, 2006.

“The human allergens of mesquite (Prosopis juliflora),” Killian, S. and McMichael, J., Clinical and Molecular Allergy, 2004, 2:8 [ Read full article... ]

“A Trial Study: The Effect of Low Dose Human Chorionic Gonadotropin on the Symptoms of Benign Prostatic Hyperplasia,” Michael F. Godschalk, Kenneth A. Unice, Donald Bergner, P. Gary Katz, Thomas Mulligan, and John McMichael. The Journal of Urology, Volume 170, 1264-1269, 2003. [ Read Abstract... ] (subscription login required to view full article)

“Cross-reactivity of mesquite tree pollen with deciduous tree pollens [abstract],” Killian S, McMichael J., The Journal of Allergy and Clinical Immunology, 2002, 109:s137. [ JACI website..  ] (subscription login required to view full article)

“Enhancement of radiosensitivity of the MCF-7 breast cancer cell line with human chorionic gonadotropin,” Sunthorn Pond-Tor, Ryan G. Rhodes, Paul E. Dahlberg, John T. Leith, John McMichael, and Albert E. Dahlberg. Breast Cancer Research and Treatment, Volume 72: 45-51, 2002. [ Read full article... ]

“Open-Label Pilot Study of the Safety and Efficacy of LDI-200 in the Treatment of Cancer-Associated Pain,” Lloyd Saberski, Hanne Peterson, and John McMichael. The Pain Clinic, June 2001.

“Modulating Activity of Human Chorionic Gonadotropin on Growth and Tumorigenesis of Prostate Cancer Cells,” Jen Wei Chiao, Karen Turo, Yang Ming Yang, Eric Feldman, Frank Traganos, Delores Halicka, Ram Kancherla, S. Robert Fatora, Tauseef Ahmed, and John McMichael. Molecular Urology, Volume 2, Number 2, 1998.

“Antigenic cross-reactivity suggested by intradermal skin test correlations,” Killian S, Fretwell SD, McMichael J., Journal of Nutritional and Environmental Medicine, 1997, 7:237-251. [ Read Abstract... ] (subscription login required to view full article)

Popular Press Articles

"Resonant Molecular Signaling," Ken Smith, Natural Awakenings, May/June 2006, p. 10.

"Bioenergetics: A New Science of Healing," Ken Smith. Shift: At the Frontiers of Consciousness, March-May 2006, No. 10., pp. 11-13, 34. [www.noetic.org]

“The Use of Natural Microdose DNA and Synthetic Minidose DNA for Respiratory Disease and Immunotherapy,” Allan Lieberman, MD.  Townsend Letter for Doctors and Patients, November 2005, pp. 68-72.
www.townsendletter.com ]

“Microdose DNA (Mucolyxir) for Alleviating Symptoms of Acute and Chronic Respiratory Diseases and Otitis Media,” Stephen W. Mamber, PhD, and John McMichael, PhD.  Townsend Letter for Doctors and Patients, November 2005, pp. 73-77.
www.townsendletter.com ]

“Hidden Allergens,” Sue Killian and Ken Smith. Natural Beauty & Health, May 2005, pp. 38-39.
[ www.nbhonline.com ]

“DNA Treatment for Respiratory Ailments,” Marcus Luxor. Natural Beauty & Health, May 2005, pp. 40-41.
[ www.nbhonline.com ]

Presentations

Paper presented at the Fourth International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 6-8 2005, at the University of Massachusetts, Amherst, MA.:
• The use of Low Dose Thimerosal for the Systematic Treatment of Herpesvirus Infections.

Paper presented at the Third International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 8-10, 2004, at the University of Massachusetts, Amherst, MA.:
• The Use of Low Dose Thimerosal for the Treatment of Type A Influenza.

Papers and poster sessions presented at the Second International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, May 28-30, 2003, at the University of Massachusetts, Amherst, MA.:
• The Use of Low Dose Thimerosal for the Treatment of Herpesvirus Infections.
• The Use of Streptolysin O for the Treatment of Scars, Adhesions, and Fibrosis.
• The Use of Human Chorionic Gonadotropin (hCG) for the Treatment of Benign
Prostatic Hyperplasia (BPH).

Paper presented at the Annual Wound Healing Society Conference, April 2003, Seattle, WA.:
• The Use of Low Dose Streptolysin O for the Treatment of Scars.